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KMID : 0388220100170030316
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Journal of the Korean Rheumatism Association
2010 Volume.17 No. 3 p.316 ~ p.320
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A Case of Systemic Lupus Erythematosus Involving the Kidneys in a Patient with IgA Nephropathy
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Song Ji-Eun
Jang Mi-Young
Oh Wang-Guk
Kim Jeong-Gwan
Park Sung-Hyun
Kim Ki-Hoe
Hwang Min-Ho
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Abstract
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Renal involvement in systemic lupus erythematosus (SLE) is a typical manifestation of the disease. The occurrence of non-lupus nephritis, especially IgA nephropathy (IgAN), in patients with SLE has rarely been reported. We describe the case of a 21-year-old woman who was diagnosed with IgAN and subacute necrotizing lymphadenitis, and her renal lesion biopsy was typical of lupus nephritis (ISN/RPS Class III). Although IgAN and lupus nephritis share some common physiopathological characteristics, their laboratory, histopathologic findings, and the extra-renal clinical manifestations are different and support a different pathogenesis. Our case highlights the importance of a renal biopsy in patients with lupus and urinary alterations despite underlying IgAN. A correct diagnosis would permit the most appropriate immunosuppressive treatments to be considered.
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KEYWORD
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Systemic lupus erythematosus, Lupus nephritis, IgA nephropathy, Subacute necrotizing lymphadenitis
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